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25 mg daily and oral micronized estradiol 1 mg daily result in similar plasma concentrations of estrone and estradiol 150 300 pg ml and 30 50 pg ml for micronized estradiol, respectively oral estradiol is extensively metabolized into estrone during hepatic first-pass metabolism , 15 although this does not account for equilin and other equine estrogens involved in the effects of premarin, which may be significantly more potent in comparison to estrone.
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The most common side effects associated with premarin use are vaginal yeast infections, vaginal spotting or bleeding, painful menses, and cramping of the legs.
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